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BRANE Clust: cluster-assisted gene regulatory network inference refinement

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The joined Gene Regulatory Network (GRN)  inference and clustering tool BRANE Clust has just been published in BRANE Clust: cluster-assisted gene regulatory network inference refinement in IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2017 (doi:10.1109/TCBB.2017.2688355).

It is also featured on RNA-seq blog and OMIC tools.

Alternative versions are available as a preprint, on biorxiv, with a page and software and in HAL. Another brick in the BRANE series wall, a series of bioinformatics tools based on graphs and optimization, dedicated to -omics gene expression data for GRN (Gene Regulatory Network) inference.

While traditional Next-generation sequencing (NGS) pipelines often combine motley assumptions (correlation, normalization, clustering, inference), this work is an first step toward gracefully combining network inference and clustering. 
BRANE Clust works as a post-processing tool upon classical network thresholding refinement. From a complete weighted networ…